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Odrun Arna Gederaas

Odrun Arna Gederaas

Professor

Department of Natural Sciences >

 

+47 38 14 19 44

+47 473 55 838

Office:
J1014 ( Universitetsveien 25, Kristiansand )

Scientific publications

  • Gederaas, Odrun Arna; Lindgren, Mikael; Stigen, Kari; Høgset, Anders Skog; Hirschberg, Henry (2024). Pharmacokinetics of disulphonated tetraphenyl chlorin (fimaporfin/TPCS2a) in a rat glioma model - methodology. Journal of Porphyrins and Phthalocyanines. ISSN: 1088-4246. doi:10.1142/S1088424624500238.
  • Hageberg, Ingvild Uri; Arja, Katriann; Vindstad, Benedikte Emilie; Bergvoll, Johannes; Gederaas, Odrun Arna; Melø, Thor Bernt; Nilsson, K Peter R; Lindgren, Mikael (2023). Photophysics of Glycosylated Ring-Fused Chlorin Complexes and Their Photosensitizing Effects on Cancer Cells. ChemPhotoChem. ISSN: 2367-0932. 7 (8). doi:10.1002/cptc.202300028.
  • Gederaas, Odrun Arna; Sharma, Animesh; Mbarak, Saide; Sporsheim, Bjørnar; Høgset, Anders; Bogoeva, Vanya; Slupphaug, Geir; Hagen, Lars (2023). Proteomic analysis reveals mechanisms underlying increased efficacy of bleomycin by photochemical internalization in bladder cancer cells. Molecular Omics. ISSN: 2515-4184. 19 (7). s 585 - 597. doi:10.1039/d2mo00337f.
  • Desgranges, Stéphane; Juzenas, Petras; Vasovic, Vlada; Gederaas, Odrun Arna; Lindgren, Mikael; Warloe, Trond; Qian, Peng; Contino-Pepin, Christiane (2022). Amphiphilic Protoporphyrin IX Derivatives as New Photosensitizing Agents for the Improvement of Photodynamic Therapy. Biomedicines. 10 (2). doi:10.3390/biomedicines10020423.
  • Gederaas, Odrun Arna; Sørensen, Andreas; Lindgren, Mikael; Melø, Thor Bernt; Altin, Dag; Flatby, Ellen M. Samdahl; Høgset, Anders; Hoff, Bård Helge (2022). Synthesis and in vitro evaluation of a novel thienopyrimidine with phototoxicity towards rat glioma F98 cells. Journal of Photochemistry and Photobiology. ISSN: 2666-4690. 10
  • Einrem, Rune F.; Alemayehu, Abraham; Borisov, Sergey M.; Ghosh, Abhik; Gederaas, Odrun Arna (2020). Amphiphilic rhenium-oxo corroles as a new class of sensitizers for photodynamic therapy. ACS Omega. ISSN: 2470-1343. 5 (18). s 10596 - 10601. doi:10.1021/acsomega.0c01090.
  • Lindgren, Mikael; Gederaas, Odrun Arna; Siksjø, Monica; Hansen, Tom Andre; Chen, Lena; Mettra, Bastien; Andraud, Chantal; Monnereau, Cyrille (2020). Influence of Polymer Charge on the Localization and Dark- and Photo-Induced Toxicity of a Potential Type I Photosensitizer in Cancer Cell Models. Molecules. ISSN: 1431-5157. 25 (5). doi:10.3390/molecules25051127.
  • Shi, L.; Pohla, H.; Buchner, A.; Zhang, L.; Pongratz, T.; Ruhm, A.; Zimmermann, W.; Gederaas, Odrun Arna; Wang, X; Stepp, Herbert; Stroka, R. (2020). MOP-dependent enhancement of methadone on the effectiveness of ALA-PDT for A172 cells by upregulating phosphorylated JNK and BCL2.. Photodiagnosis and Photodynamic Therapy. ISSN: 1572-1000. 30s 101657. doi:10.1016/j.pdpdt.2020.101657.
  • Callaghan, Susan; Vindstad, Benedikte Emilie; Flanagan, Keith J.; Melø, Thor Bernt; Lindgren, Mikael; Grendstad, Kristin; Gederaas, Odrun Arna; Senge, Mathias O. (2020). Structural, photophysical, and photobiological studies on BODIPY‐anthracene dyads. ChemPhotoChem. ISSN: 2367-0932. doi:10.1002/cptc.202000191.
  • Nguyen, Jimmi; Madsen J, Steen; Gederaas, Odrun Arna; Berg, Kristian; Høgset, Anders; Hirschberg, Henry (2020). Ultrasonic Activation of the Sonosensitizer Fimaporfin Enhances the Efficacy of Chemotherapy: An In Vitro Study on Rat Glioma Cells.. Journal of Cancer Research and Clinical Oncology. ISSN: 0171-5216. doi:10.31487/j.COR.2020.05.10.
  • Gederaas, Odrun Arna; Husebye, Harald; Johnsson, Anders Carl G.; Callaghan, Susan; Brunsvik, Anders (2019). In vitro and in vivo effects of HAL on porphyrin production in rat bladder cancer cells (AY27). Journal of Porphyrins and Phthalocyanines. ISSN: 1088-4246. 23s 813 - 820. doi:10.1142/S1088424619500615.
  • Shi, Lei; Buchner, Alexander; Pohla, Heike; Pongratz, Thomas; Rühm, Adrian; Zimmermann, Wolfgang; Gederaas, Odrun Arna; Zhang, Linglin; Wang, Xiuli; Stepp, Herbert; Sroka, Ronald (2019). Methadone enhances the effectiveness of 5‐aminolevulinic acid‐based photodynamic therapy for squamous cell carcinoma and glioblastoma in vitro. Journal of Biophotonics. ISSN: 1864-063X. 12:201800468 (10). s 1 - 9. doi:10.1002/jbio.201800468.
  • Søgaard, Caroline Krogh; Blindheim, Augun; Røst, Lisa Marie; Petrovic, Voin; Nepal, Anala; Bachke, Siri; Liabakk, Nina-Beate; Gederaas, Odrun Arna; Viset, Trond; Arum, Carl-Jørgen; Bruheim, Per; Otterlei, Marit (2018). "Two hits - one stone" increased efficacy of cisplatin-based therapies by targeting PCNA's role in both DNA repair and cellular signaling. OncoTarget. ISSN: 1949-2553. 9 (65). s 32448 - 32465. doi:10.18632/oncotarget.25963.
  • Holien, Toril; Gederaas, Odrun Arna; Darvekar, Sagar; Christensen, Eidi; Qian, Peng (2018). Comparison Between 8-Methoxypsoralen and 5-Aminolevulinic Acid in Killing T Cells of Photopheresis Patients Ex Vivo. Lasers in Surgery and Medicine. ISSN: 0196-8092. 50 (5). s 469 - 475. doi:10.1002/lsm.22806.
  • Haug, Markus; Brede, Gaute; Håkerud, Monika; Nedberg, Anne Grete Gargul; Gederaas, Odrun Arna; Flo, Trude Helen; Edwards, Victoria Tudor; Selbo, Pål Kristian; Høgset, Anders; Halaas, Øyvind (2018). Photochemical internalization of peptide antigens provides a novel strategy to realize therapeutic cancer vaccination. Frontiers in Immunology. ISSN: 1664-3224. 9:650s 1 - 14. doi:10.3389/fimmu.2018.00650.
  • Gederaas, Odrun Arna; Johnsson, Anders Carl G.; Berg, Kristian; Manandhar, Rojlina; Shrestha, Chetana; Skåre, Daniel; Ekroll, Ingvild Kinn; Høgset, Anders; Hjelde, Astrid (2017). Photochemical internalization in bladder cancer-development of an orthotopic in vivo model. Photochemical and Photobiological Sciences. ISSN: 1474-905X. 16 (11). s 1664 - 1676. doi:10.1039/c7pp00176b.
  • Chatzisideri, T; Thysiadis, S; Katsamakas, S; Dalezis, P; Sigala, I; Lazarides, T; Nikolakaki, E; Trafalis, D; Gederaas, Odrun Arna; Lindgren, Mikael; Sarli, V (2017). Synthesis and biological evaluation of a Platinum(II)-c(RGDyK) conjugate for integrin-targeted photodynamic therapy. European Journal of Medicinal Chemistry. ISSN: 0223-5234. 141s 221 - 231. doi:10.1016/j.ejmech.2017.09.058.
  • Alemayehu, Abraham; Day, Nicholas U.; Mani, Tomoyasu; Rudine, Alexander B.; Kolle, Ekaney Thomas; Gederaas, Odrun Arna; Vinogradov, Sergei A.; Wamser, Carl C.; Ghosh, Abhik (2016). Gold Tris(carboxyphenyl)corroles as Multifunctional Materials: Room Temperature Near-IR Phosphorescence and Applications to Photodynamic Therapy and Dye-Sensitized Solar Cells. ACS Applied Materials & Interfaces. ISSN: 1944-8244. 8 (29). s 18935 - 18942. doi:10.1021/acsami.6b04269.
  • Helander, Linda; Sharma, Animesh; Krokan, Hans Einar; Plaetzer, Kristjan; Krammer, Barbara; Tortik, Nicole; Gederaas, Odrun Arna; Slupphaug, Geir; Hagen, Lars (2015). Photodynamic treatment with hexyl-aminolevulinate mediates reversible thiol oxidation in core oxidative stress signaling proteins. Molecular Biosystems. ISSN: 1742-206X. doi:10.1039/c5mb00744e.
  • Bogoeva, Vanya; Siksjø, Monica; Sæterbø, Kristin Grendstad; Melø, Thor Bernt; Bjørkøy, Astrid; Lindgren, Mikael; Gederaas, Odrun Arna (2016). Ruthenium porphyrin-induced photodamage in bladder cancer cells. Photodiagnosis and Photodynamic Therapy. ISSN: 1572-1000. 14s 9 - 17. doi:10.1016/j.pdpdt.2016.01.012.
  • Gederaas, Odrun Arna; Hauge, Anette; Ellingsen, Pål Gunnar; Berg, Kristian; Altin, Dag; Bardal, Tora; Høgset, Anders; Lindgren, Mikael (2015). Photochemical internalization of bleomycin and temozolomide – in vitro studies on the glioma cell line F98. Photochemical and Photobiological Sciences. ISSN: 1474-905X. 14 (7). s 1357 - 1366. doi:10.1039/c5pp00144g.
  • Baglo, Yan; Qian, Peng; Hagen, Lars; Berg, Kristian; Høgset, Anders; Drabløs, Finn; Gederaas, Odrun Arna (2015). Studies of the photosensitizer disulfonated meso-tetraphenyl chlorin in an orthotopic rat bladder tumor model. Photodiagnosis and Photodynamic Therapy. ISSN: 1572-1000. 12 (1). s 58 - 66. doi:10.1016/j.pdpdt.2014.12.005.
  • Amundsen, Tore; Sundstrøm, Stein Harald; Buvik, Turid; Gederaas, Odrun; Haaverstad, Rune (2013). Can dogs smell lung cancer? First study using exhaled breath and urine screening in unselected patients with suspected lung cancer. Acta Oncologica. ISSN: 0284-186X. 53 (3). s 307 - 315. doi:10.3109/0284186X.2013.819996.
  • Baglo, Yan; Hagen, Lars; Høgset, Anders; Drabløs, Finn; Otterlei, Marit; Gederaas, Odrun Arna (2014). Enhanced efficacy of bleomycin in bladder cancer cells by photochemical internalization. BioMed Research International. ISSN: 2314-6133. 14 (74). doi:10.1155/2014/921296.
  • Gederaas, Odrun Arna; Søgaard, Caroline Danielsen; Viset, Trond; Bachke, Siri; Bruheim, Per; Arum, Carl-Jørgen; Otterlei, Marit (2014). Increased anticancer efficacy of intravesical mitomycin C therapy when combined with a PCNA targeting peptide. Translational Oncology. ISSN: 1944-7124. 7 (6). s 812 - 823. doi:10.1016/j.tranon.2014.10.005.
  • Helander, Linda; Krokan, Hans Einar; Johnsson, Anders Carl G.; Gederaas, Odrun Arna; Plaetzer, Kristjan (2014). Red versus blue light illumination in hexyl 5-aminolevulinate photodynamic therapy: the influence of light color and irradiance on the treatment outcome in vitro. Journal of Biomedical Optics. ISSN: 1083-3668. 19:088002 (8). doi:10.1117/1.JBO.19.8.088002.
  • Baglo, Yan; Gabrielsen, Mari; Sylte, Ingebrigt; Gederaas, Odrun Arna (2013). Homology Modeling of Human -Butyric Acid Transporters and the Binding of Pro-drugs 5-Aminolevulinic Acid and Methyl Aminolevulinic Acid used in Photodynamic Therapy. PLOS ONE. ISSN: 1932-6203. 8 (6). doi:10.1371/journal.pone.0065200.
  • Ekroll, Ingvild Kinn; Gederaas, Odrun Arna; Helander, Linda; Hjelde, Astrid; Melø, Thor Bernt; Johnsson, Anders (2011). Photo induced hexylaminolevulinate destruction of rat bladder cells AY-27. Photochemical and Photobiological Sciences. ISSN: 1474-905X. 10 (6). s 1072 - 1079. doi:10.1039/c0pp00393j.
  • Baglo, Yan; Sousa, Mirta; Slupphaug, Geir; Hagen, Lars; Håvåg, Sissel; Helander, Linda; Zub, Kamila; Krokan, Hans Einar; Gederaas, Odrun Arna (2011). Photodynamic therapy with hexyl aminolevulinate induces carbonylation, posttranslational modifications and changed expression of proteins in cell survival and cell death pathways. Photochemical and Photobiological Sciences. ISSN: 1474-905X. 10 (7). s 1137 - 1145. doi:10.1039/c0pp00369g.
  • Arum, Carl-Jørgen; Gederaas, Odrun Arna; Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Hjelde, Astrid; Krokan, Hans Einar; Svaasand, Lars O.; Chen, Duan; Zhao, Chun-Mei (2011). Tissue responses to hexyl 5-aminolevulinate-induced photodynamic treatment in syngeneic orthotopic rat bladder cancer model: possible pathways of action. Journal of Biomedical Optics. ISSN: 1083-3668. 16 (2). doi:10.1117/1.3536536.
  • Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Arum, Carl-Jørgen; Hjelde, Astrid; Zhao, Chun-Mei; Chen, Duan; Krokan, Hans Einar; Svaasand, Lars O. (2008). Monitoring of Hexyl 5-aminolevulinate Induced Photodynamic Therapy in Rat Bladder Cancer by Optical Spectroscopy. Journal of Biomedical Optics. ISSN: 1083-3668. 13 (4). s 044031-1 - 044031-9. doi:10.1117/1.2967909.
  • Larsen, Eivind La Puebla; Randeberg, Lise Lyngsnes; Gederaas, Odrun Arna; Krokan, Hans Einar; Hjelme, Dag Roar; Svaasand, Lars O. (2007). In vitro study on methemoglobin formation in erythrocytes following hexyl-aminolevulinate induced photodynamic therapy. PROGRESS IN BIOMEDICAL OPTICS AND IMAGING Optical Methods for Tumor Treatment and Detection: Mechanisms and Techniques in Photodynamic Therapy XVI. ISBN: 9780819465405. SPIE - International Society for Optical Engineering. 642719.
  • Tønnessen, Hanne Hjorth; Brunsvik, Anders; Løseth, Kirsti; Bergh, Kåre; Gederaas, Odrun Arna (2007). Photoreactivity of biologically active compounds. XVIII. Photostability of ofloxacin in the solid state and in a tablet formulation. Pharmazie. ISSN: 0031-7144. 62s 105 - 111.
  • Tønnesen, Hanne Hjorth; Brunsvik, Anders; Løseth, Kirsti; Bergh, Kåre; Gederaas, Odrun A. (2007). Photoreactivity of biologically active compounds. XVIII. Photostability of ofloxacin in the solid state and in a tablet formulation. Pharmazie. ISSN: 0031-7144. 62s 105 - 111. doi:10.1691/ph.2007.2.5184.
  • Schønberg, Svanhild Margrethe Arentz; Lundemo, Anne Gøril; Fladvad, Torill; Holmgren, Kristin; Bremseth, Hilde; Nilsen, Asbjørn Magne; Gederaas, Odrun Arna; Tvedt, Kåre E; Egeberg, Kjartan Wøllo; Krokan, Hans Einar (2006). Closely related colon cancer cell lines display different sensitivity to polyunsaturated fatty acids, accumulate different lipid classes and downregulate sterol regulatory element-binding protein 1. The FEBS Journal. ISSN: 1742-464X. 273s 2749 - 2765.
  • Gederaas, Odrun Arna; Schønberg, Svanhild Margrethe Arentz; Ramstad, Ståle; Berg, Kristian; Johnsson, Anders Carl G.; Krokan, Hans Einar (2005). Cell specific effects of polyunsaturated fatty acids on 5-aminolevulinic acid based photosensitization. Photochemical and Photobiological Sciences. ISSN: 1474-905X. 4doi:10.1039/b502000j.
  • Bruzell Roll, Ellen; Christensen, Terje; Gederaas, Odrun Arna (2005). Effects of bilirubin and phototherapy on osmotic fragility and haematoporphyrin-induced photohaemolysis of normal erythrocytes and spherocytes. Acta Paediatrica. Supplement. ISSN: 0803-5326. 94s 1443 - 1447.
  • Hjelde, Astrid; Gederaas, Odrun Arna; Krokan, Hans Einar; Brubakk, Alf O (2005). Lack of effect of hyperoxia on photodynamic therapy and lipid peroxidation in three different cancer cell lines. Medical Science Monitor. ISSN: 1234-1010. 11 (10). s 351 - 356.
  • Gederaas, Odrun A.; Holroyd, Andrew; Brown, Stanley B.; Vernon, David; Moan, Johan Emilian; Berg, Kristian (2001). 5-Aminolaevolunic Acid Methyl Ester Transport on Amino Acid Carriers in a Human Colon Adenocarcinoma Cell Line. Photochemistry and Photobiology. ISSN: 0031-8655. 73(2)s 164 - 169.
  • Gederaas, Odrun Arna; Holroyd, Andrew; Brown, Stanley B.; Vernon, David; Moan, Johan; Berg, Kristian (2001). 5-Aminolaevulinic Acid Methyl Ester Transport On Amino Acid Carriers In a Human Colon Adenocarcinoma Cell Line. Photochemistry and Photobiology. ISSN: 0031-8655. 73 (2)s xx.
  • Gederaas, Odrun; Brown, SB; Vernon, D.; Moan, J.; Berg, K (2001). 5-aminolaevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochemistry and Photobiology. ISSN: 0031-8655. 73s 164 - 169.
  • Gederaas, Odrun Arna; Lagerberg, Johan W.M.; Brekke, Ole-Lars; Berg, K; Dubbelman, TMAR (2000). 5-aminilevulinic acid induced lipid peroxidation after illumination on humane colon carcinoma cells with effects of a-tocopherol stimulation. Cancer Letters. ISSN: 0304-3835. 159s 23 - 32.
  • Gederaas, Odrun Arna; Holroyd, A; Brown, S; Vernon, D; Moan, J; Berg, K (2000). 5-aminolevulinic acid methyl ester transport on amino acid carriers in a human colon adenocarcinoma cell line. Photochemistry and Photobiology. ISSN: 0031-8655. s xxx.
  • Rud, E; Gederaas, Odrun Arna; Høgset, OA; Berg, K (2000). 5-aminolevulinic acid, but not 5-aminolevulinic acid esters, is transported into adenocarcinoma cells by system BETA transporters. Photochemistry and Photobiology. ISSN: 0031-8655. 71s 640 - 647.
  • Gederaas, Odrun Arna; Berg, K; Romslo, I. (2000). A comparative study of normal and reverse phase high pressure liquid chromatography for analysis of porphyrins accumulated after 5-aminolevulinic acid treatment of colon adenocarcinoma cells. Cancer Letters. ISSN: 0304-3835. 150s 205 - 213.
  • Gederaas, Odrun Arna; Rasch, MR; Berg, K; Lagerberg, Johan W.M.; Dubbelman, TMAR (2000). Photodynamically induced effects in colon carcinoma cells (WiDr) by endogenous photosensitizers generated by incubation with 5-aminolaevulinic acid. Journal of Photochemistry and Photobiology. B: Biology. ISSN: 1011-1344. 49s 162 - 170.
  • Gederaas, Odrun Arna; Rasch, Monique H; Berg, Kristian; Lagerberg, Johan W.M.; Dubbelman, Tom M.A.R. (1999). Photodynamically induced effects in colon carcinoma cells (WiDr) by endegenous photosensitizers generated by incubation with 5-aminolaevulinic acid. Journal of Photochemistry and Photobiology. B: Biology. ISSN: 1011-1344. 49s 162 - 170.
  • Gederaas, Odrun Arna; Thorstensen, Ketil; Romslo, I. (1996). The effect of brief illumination on intracellular free calcium concentration in cells with 5-aminolevulinic acid-induced protoporphyrin IX. Scandinavian Journal of Clinical and Laboratory Investigation. ISSN: 0036-5513. 56
  • Tømmerås, BA; Mustaparta, Hanna; Gederaas, Odrun; Anthonsen, Thorleif (1987). Single cell responses combined with gas-chromatographic separation of host volatiles in bark beetles. Chemical Senses. ISSN: 0379-864X. 12 (1). s 193 - 194.
  • Gederaas, Odrun Arna (1988). Hepatocyte iron uptake - a plasma membrane process or an endosomal process?. ISBN: 0-306-43092-4. Plenum publishing corporation. s 3.
  • Swaminathan, Priyanka; Sundnes, Marikken L; Lindgren, Mikael; Gederaas, Odrun Arna; Klingstedt, Thérese; Nyström, Sofie; Hammarström, Per; Nilsson, Peter; Van Den Berge, Nathalie (2024). Hyperspectral imaging of amyloid asynuclein(asyn) in HEK293 cells using Luminescent conjugated oligothiophenes(LCOs).
  • Swaminathan, Priyanka; Lindgren, Mikael; Gederaas, Odrun Arna (2024). Use of in-vitro cell models and protein fluorescent markers for studying amyloid related diseases.
  • Swaminathan, Priyanka; Sundnes, Marikken L; Vindstad, Benedikte; Gederaas, Odrun Arna; Lindgren, Mikael; Klingstedt, Thérese; Hellstrand, Ebba; Nyström, Sofie; Hammarström, Per; Nilsson, Peter (2023). Use of in-vitro cell-models in understanding amyloidosis.
  • Sundnes, Marikken L; Swaminathan, Priyanka; Gederaas, Odrun Arna; Lindgren, Mikael; Klingstedt, Thérese; Hellstrand, Ebba; Nyström, Sofie; Hammarström, Per; Nilsson, K. Peter R.; Van Den Berge, Nathalie (2023). Hyperspectral microscopy and ligand screening of TTR amyloid fibrils.

Last changed: 8.05.2023 15:05